This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CER1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CER1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CER1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:14,546,850–14,548,008 | 175.3 kb | Distal (>10kb) Multiome | 219 | |
| chr9:14,563,500–14,564,741 | 158.5 kb | Distal (>10kb) Multiome | 205 | |
| chr9:14,692,495–14,694,738 | 29.3 kb | Distal (>10kb) Multiome | 739 | |
| chr9:14,707,894–14,718,960 | 6.6 kb | Proximal (<10kb) Multiome | 491 | |
| chr9:14,722,051–14,724,133 | 158 bp | At TSS Multiome | 397 | |
| chr9:14,724,281–14,724,938 | 1.5 kb | Proximal (<10kb) | 15 | |
| chr9:14,725,531–14,725,837 | 2.8 kb | Proximal (<10kb) | 7 | |
| chr9:14,725,956–14,726,331 | 3.2 kb | Proximal (<10kb) | 8 | |
| chr9:14,727,245–14,727,819 | 4.5 kb | Proximal (<10kb) | 9 | |
| chr9:14,731,369–14,731,981 | 8.6 kb | Proximal (<10kb) | 18 | |
| chr9:14,746,175–14,747,463 | 24.4 kb | Distal (>10kb) Multiome | 117 | |
| chr9:14,752,089–14,753,309 | 29.9 kb | Distal (>10kb) Multiome | 147 | |
| chr9:14,992,603–14,993,831 | 270.6 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the CER1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.