This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for CELSR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELSR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELSR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,372,864–48,373,543 | 289.7 kb | Distal (>10kb) Multiome | 49 | |
| chr3:48,428,528–48,430,504 | 232.8 kb | Distal (>10kb) Multiome | 910 | |
| chr3:48,439,801–48,440,548 | 222.7 kb | Distal (>10kb) Multiome | 787 | |
| chr3:48,446,396–48,447,180 | 216.1 kb | Distal (>10kb) Multiome | 767 | |
| chr3:48,465,344–48,466,310 | 197.1 kb | Distal (>10kb) Multiome | 670 | |
| chr3:48,472,636–48,473,658 | 189.6 kb | Distal (>10kb) Multiome | 821 | |
| chr3:48,503,451–48,504,839 | 158.8 kb | Distal (>10kb) Multiome | 419 | |
| chr3:48,556,022–48,557,666 | 105.8 kb | Distal (>10kb) Multiome | 794 | |
| chr3:48,558,131–48,558,793 | 104.5 kb | Distal (>10kb) Multiome | 503 | |
| chr3:48,608,816–48,610,628 | 53.3 kb | Distal (>10kb) Multiome | 850 | |
| chr3:48,634,696–48,636,251 | 27.3 kb | Distal (>10kb) Multiome | 898 | |
| chr3:48,655,787–48,657,257 | 6.4 kb | Proximal (<10kb) Multiome | 438 | |
| chr3:48,661,275–48,664,636 | 1.2 kb | Proximal (<10kb) Multiome | 1248 | |
| chr3:48,685,362–48,686,531 | 23.0 kb | Distal (>10kb) Multiome | 770 | |
| chr3:48,716,958–48,717,863 | 54.4 kb | Distal (>10kb) Multiome | 634 | |
| chr3:48,847,059–48,848,224 | 184.9 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 236.0 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 255.9 kb | Distal (>10kb) Multiome | 877 | |
| chr3:49,006,738–49,008,496 | 345.0 kb | Distal (>10kb) Multiome HiCAR | 955 |
Genomic view of the CELSR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.