Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CELF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CELF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CELF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:9,561,614–9,562,639 | 1455.8 kb | Distal (>10kb) Multiome HiCAR | 177 | |
| chr10:10,938,714–10,939,585 | 78.9 kb | Distal (>10kb) Multiome | 122 | |
| chr10:10,974,552–10,976,060 | 42.9 kb | Distal (>10kb) Multiome | 77 | |
| chr10:11,017,341–11,018,824 | 70 bp | At TSS Multiome | 387 | |
| chr10:11,021,421–11,022,810 | 3.5 kb | Proximal (<10kb) | 71 | |
| chr10:11,023,004–11,023,334 | 5.0 kb | Proximal (<10kb) | 28 | |
| chr10:11,164,997–11,166,386 | 148.0 kb | Distal (>10kb) Multiome | 473 | |
| chr10:11,270,256–11,271,141 | 252.8 kb | Distal (>10kb) Multiome | 404 |
Genomic view of the CELF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.