Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDYL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDYL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDYL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:4,647,371–4,648,131 | 125.3 kb | Distal (>10kb) Multiome | 773 | |
| chr6:4,682,186–4,682,977 | 90.6 kb | Distal (>10kb) Multiome | 88 | |
| chr6:4,774,740–4,777,263 | 3.0 kb | Proximal (<10kb) Multiome | 707 | |
| chr6:4,864,483–4,865,426 | 91.8 kb | Distal (>10kb) Multiome | 169 | |
| chr6:4,925,466–4,925,943 | 152.7 kb | Distal (>10kb) Multiome | 71 | |
| chr6:5,003,235–5,004,614 | 230.8 kb | Distal (>10kb) Multiome | 925 | |
| chr6:5,025,821–5,026,808 | 253.3 kb | Distal (>10kb) Multiome | 434 | |
| chr6:5,036,286–5,036,731 | 263.4 kb | Distal (>10kb) Multiome | 261 |
Genomic view of the CDYL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.