The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDKL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDKL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDKL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:134,070,573–134,071,963 | 299.8 kb | Distal (>10kb) Multiome | 666 | |
| chr5:134,099,891–134,100,749 | 270.9 kb | Distal (>10kb) Multiome | 227 | |
| chr5:134,101,617–134,102,291 | 268.9 kb | Distal (>10kb) Multiome | 334 | |
| chr5:134,113,043–134,116,112 | 255.3 kb | Distal (>10kb) Multiome | 637 | |
| chr5:134,140,528–134,140,995 | 230.3 kb | Distal (>10kb) Multiome | 342 | |
| chr5:134,176,142–134,177,562 | 194.0 kb | Distal (>10kb) Multiome | 952 | |
| chr5:134,184,086–134,184,650 | 186.7 kb | Distal (>10kb) Multiome HiCAR | 289 | |
| chr5:134,225,248–134,227,248 | 144.8 kb | Distal (>10kb) Multiome | 1043 | |
| chr5:134,366,722–134,367,362 | 3.9 kb | Proximal (<10kb) Multiome | 682 | |
| chr5:134,370,722–134,372,303 | 215 bp | At TSS Multiome | 1080 | |
| chr5:134,411,465–134,412,433 | 40.9 kb | Distal (>10kb) Multiome | 989 | |
| chr5:134,465,626–134,467,213 | 94.9 kb | Distal (>10kb) Multiome | 926 | |
| chr5:134,506,114–134,506,990 | 135.3 kb | Distal (>10kb) Multiome HiCAR | 644 | |
| chr5:134,511,761–134,512,800 | 141.3 kb | Distal (>10kb) Multiome | 505 | |
| chr5:134,523,964–134,528,361 | 156.5 kb | Distal (>10kb) Multiome HiCAR | 1077 | |
| chr5:134,539,671–134,540,206 | 168.9 kb | Distal (>10kb) Multiome HiCAR | 144 | |
| chr5:134,586,828–134,587,543 | 216.2 kb | Distal (>10kb) Multiome HiCAR | 407 | |
| chr5:134,632,348–134,633,007 | 261.8 kb | Distal (>10kb) Multiome | 1019 | |
| chr5:134,648,377–134,649,305 | 277.7 kb | Distal (>10kb) Multiome | 995 |
Genomic view of the CDKL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.