The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for CDK16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,129,095–47,129,667 | 88.9 kb | Distal (>10kb) Multiome | 538 | |
| chrX:47,144,621–47,145,590 | 73.1 kb | Distal (>10kb) Multiome | 649 | |
| chrX:47,190,608–47,191,059 | 27.5 kb | Distal (>10kb) Multiome | 536 | |
| chrX:47,191,642–47,192,226 | 26.2 kb | Distal (>10kb) Multiome | 138 | |
| chrX:47,193,067–47,193,943 | 24.5 kb | Distal (>10kb) Multiome | 651 | |
| chrX:47,217,449–47,219,337 | 202 bp | At TSS Multiome | 736 | |
| chrX:47,232,860–47,233,865 | 15.3 kb | Distal (>10kb) Multiome | 684 | |
| chrX:47,321,409–47,321,883 | 103.4 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 143.9 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 163.9 kb | Distal (>10kb) Multiome HiCAR | 17 | |
| chrX:47,482,474–47,483,311 | 264.5 kb | Distal (>10kb) Multiome | 573 |
Genomic view of the CDK16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.