This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDH11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDH11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDH11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:65,117,819–65,118,270 | 4.1 kb | Proximal (<10kb) | 252 | |
| chr16:65,119,969–65,120,369 | 2.0 kb | Proximal (<10kb) | 49 | |
| chr16:65,120,735–65,123,829 | 28 bp | At TSS Multiome | 341 | |
| chr16:65,125,791–65,126,156 | 3.4 kb | Proximal (<10kb) | 55 | |
| chr16:65,234,820–65,236,377 | 112.7 kb | Distal (>10kb) Multiome | 257 | |
| chr16:65,318,705–65,319,215 | 196.6 kb | Distal (>10kb) Multiome | 118 |
Genomic view of the CDH11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.