Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDCA7L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDCA7L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDCA7L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:21,771,740–21,772,441 | 173.8 kb | Distal (>10kb) Multiome | 259 | |
| chr7:21,923,223–21,923,971 | 22.2 kb | Distal (>10kb) Multiome | 206 | |
| chr7:21,941,394–21,942,273 | 4.0 kb | Proximal (<10kb) Multiome | 325 | |
| chr7:21,944,675–21,944,900 | 1.0 kb | Proximal (<10kb) | 267 | |
| chr7:21,945,376–21,946,649 | 45 bp | At TSS Multiome | 738 | |
| chr7:21,965,322–21,966,224 | 19.9 kb | Distal (>10kb) Multiome | 87 | |
| chr7:21,971,858–21,972,791 | 26.5 kb | Distal (>10kb) Multiome | 84 | |
| chr7:22,082,625–22,083,698 | 137.2 kb | Distal (>10kb) Multiome | 664 | |
| chr7:22,193,275–22,194,024 | 247.9 kb | Distal (>10kb) Multiome | 146 |
Genomic view of the CDCA7L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.