The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,054,311–40,054,810 | 233.4 kb | Distal (>10kb) Multiome | 694 | |
| chr17:40,062,700–40,063,624 | 224.9 kb | Distal (>10kb) Multiome | 609 | |
| chr17:40,075,390–40,075,997 | 212.2 kb | Distal (>10kb) Multiome | 556 | |
| chr17:40,098,950–40,099,858 | 188.6 kb | Distal (>10kb) Multiome | 997 | |
| chr17:40,100,155–40,101,301 | 187.1 kb | Distal (>10kb) Multiome | 954 | |
| chr17:40,111,702–40,112,164 | 176.0 kb | Distal (>10kb) Multiome | 678 | |
| chr17:40,113,185–40,113,691 | 174.5 kb | Distal (>10kb) Multiome | 864 | |
| chr17:40,121,452–40,123,602 | 166.0 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,139,909–40,141,108 | 147.5 kb | Distal (>10kb) Multiome | 1121 | |
| chr17:40,177,152–40,178,398 | 110.4 kb | Distal (>10kb) Multiome | 329 | |
| chr17:40,191,326–40,192,022 | 96.1 kb | Distal (>10kb) Multiome | 588 | |
| chr17:40,218,712–40,219,963 | 68.5 kb | Distal (>10kb) Multiome | 901 | |
| chr17:40,287,308–40,288,608 | 119 bp | At TSS Multiome | 870 | |
| chr17:40,306,565–40,307,697 | 19.2 kb | Distal (>10kb) Multiome | 366 | |
| chr17:40,316,576–40,317,119 | 28.9 kb | Distal (>10kb) Multiome | 557 | |
| chr17:40,317,794–40,318,727 | 30.3 kb | Distal (>10kb) Multiome | 799 | |
| chr17:40,341,205–40,342,644 | 54.0 kb | Distal (>10kb) Multiome | 835 | |
| chr17:40,344,939–40,346,042 | 57.5 kb | Distal (>10kb) Multiome | 730 | |
| chr17:40,362,469–40,363,831 | 75.0 kb | Distal (>10kb) Multiome | 846 | |
| chr17:40,417,289–40,418,494 | 130.2 kb | Distal (>10kb) Multiome | 793 | |
| chr17:40,422,953–40,423,555 | 135.3 kb | Distal (>10kb) Multiome | 242 | |
| chr17:40,442,866–40,444,146 | 155.6 kb | Distal (>10kb) Multiome | 774 | |
| chr17:40,483,550–40,484,556 | 196.1 kb | Distal (>10kb) Multiome | 84 | |
| chr17:40,499,140–40,499,767 | 211.7 kb | Distal (>10kb) Multiome | 358 | |
| chr17:42,275,506–42,277,052 | 1988.5 kb | Distal (>10kb) Multiome HiCAR | 892 |
Genomic view of the CDC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.