This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC42BPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC42BPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC42BPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:102,776,966–102,778,132 | 280.2 kb | Distal (>10kb) Multiome | 446 | |
| chr14:102,927,667–102,929,100 | 129.0 kb | Distal (>10kb) Multiome | 328 | |
| chr14:102,929,570–102,930,980 | 127.2 kb | Distal (>10kb) Multiome | 178 | |
| chr14:102,954,209–102,955,338 | 102.6 kb | Distal (>10kb) Multiome | 143 | |
| chr14:103,056,337–103,058,497 | 131 bp | At TSS Multiome | 644 | |
| chr14:103,075,052–103,076,162 | 18.2 kb | Distal (>10kb) Multiome | 656 | |
| chr14:103,091,357–103,091,855 | 34.1 kb | Distal (>10kb) Multiome | 384 | |
| chr14:103,104,655–103,105,370 | 47.6 kb | Distal (>10kb) Multiome | 618 | |
| chr14:103,122,605–103,123,921 | 65.5 kb | Distal (>10kb) Multiome | 378 | |
| chr14:103,126,688–103,127,597 | 69.6 kb | Distal (>10kb) Multiome | 313 | |
| chr14:103,188,912–103,189,569 | 131.7 kb | Distal (>10kb) Multiome | 138 | |
| chr14:103,207,129–103,207,830 | 149.8 kb | Distal (>10kb) Multiome | 200 | |
| chr14:103,333,053–103,335,386 | 276.6 kb | Distal (>10kb) Multiome | 1004 |
Genomic view of the CDC42BPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.