Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC40. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC40 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC40, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:109,944,347–109,945,486 | 235.2 kb | Distal (>10kb) Multiome | 254 | |
| chr6:109,977,901–109,979,311 | 201.9 kb | Distal (>10kb) Multiome | 637 | |
| chr6:110,039,510–110,040,377 | 140.7 kb | Distal (>10kb) Multiome | 368 | |
| chr6:110,173,609–110,173,859 | 6.6 kb | Proximal (<10kb) | 94 | |
| chr6:110,173,972–110,174,206 | 6.2 kb | Proximal (<10kb) | 36 | |
| chr6:110,178,668–110,180,832 | 417 bp | At TSS Multiome | 981 | |
| chr6:110,190,380–110,191,802 | 10.6 kb | Distal (>10kb) Multiome | 120 | |
| chr6:110,357,374–110,358,592 | 177.7 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the CDC40 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.