CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC25A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC25A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC25A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,088,196–48,089,485 | 99.3 kb | Distal (>10kb) Multiome | 933 | |
| chr3:48,187,500–48,188,989 | 169 bp | At TSS Multiome | 820 | |
| chr3:48,194,518–48,194,732 | 6.2 kb | Proximal (<10kb) | 186 | |
| chr3:48,240,728–48,241,473 | 52.8 kb | Distal (>10kb) Multiome | 843 | |
| chr3:48,300,947–48,301,746 | 113.0 kb | Distal (>10kb) Multiome | 954 | |
| chr3:48,372,864–48,373,543 | 184.9 kb | Distal (>10kb) Multiome | 49 | |
| chr3:48,428,528–48,430,504 | 241.7 kb | Distal (>10kb) Multiome HiCAR | 910 | |
| chr3:48,439,801–48,440,548 | 251.8 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:48,446,396–48,447,180 | 258.4 kb | Distal (>10kb) Multiome | 767 | |
| chr3:48,465,344–48,466,310 | 277.4 kb | Distal (>10kb) Multiome | 670 | |
| chr3:48,472,636–48,473,658 | 284.9 kb | Distal (>10kb) Multiome | 821 |
Genomic view of the CDC25A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.