The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for CD99. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD99 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD99, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:2,828,742–2,829,221 | 137.8 kb | Distal (>10kb) Multiome | 197 | |
| chrX:2,891,906–2,892,349 | 200.9 kb | Distal (>10kb) Multiome | 79 | |
| chrX:2,897,439–2,898,349 | 206.7 kb | Distal (>10kb) Multiome | 192 | |
| chrX:2,927,517–2,929,497 | 237.5 kb | Distal (>10kb) Multiome | 582 | |
| chrY:2,934,768–2,936,281 | 244.8 kb | Distal (>10kb) Multiome | 497 |
Genomic view of the CD99 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.