CD70

CD70 molecule | CD27-L, CD27L, CD27LG, TNFSF7

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Member of: DE-4

Biological processes 30 terms

B cell mediated immunity (GO:0019724)B cell proliferation (GO:0042100)CD27 signaling pathway (GO:0160162)CD27 signaling pathway (GO:0160162)T cell activation (GO:0042110)T cell activation (GO:0042110)T cell activation (GO:0042110)T cell mediated immunity (GO:0002456)T cell proliferation (GO:0042098)adaptive immune memory response involving T cells and B cells (GO:0090717)adaptive immune memory response involving T cells and B cells (GO:0090717)extracellular exosome (GO:0070062)extrinsic apoptotic signaling pathway (GO:0097191)immune response (GO:0006955)lymphocyte proliferation (GO:0046651)membrane (GO:0016020)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of T cell proliferation (GO:0042102)protein binding (GO:0005515)receptor ligand activity (GO:0048018)receptor ligand activity (GO:0048018)receptor ligand activity (GO:0048018)receptor ligand activity (GO:0048018)tumor necrosis factor receptor binding (GO:0005164)tumor necrosis factor-mediated signaling pathway (GO:0033209)

Expression (TPM)

TFs regulating CD70 0 TFs

Transcription factors with Perturb-seq knockdown data for CD70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CD70

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:6,361,350–6,362,018	229.6 kb	Distal (>10kb) Multiome	803
chr19:6,372,272–6,374,427	217.7 kb	Distal (>10kb) Multiome	925
chr19:6,392,902–6,394,077	197.7 kb	Distal (>10kb) Multiome	767
chr19:6,423,613–6,425,899	166.0 kb	Distal (>10kb) Multiome	956
chr19:6,458,960–6,460,940	130.8 kb	Distal (>10kb) Multiome	859
chr19:6,463,863–6,464,838	126.9 kb	Distal (>10kb) Multiome	526
chr19:6,470,903–6,471,589	119.9 kb	Distal (>10kb) Multiome	26
chr19:6,475,386–6,477,353	114.6 kb	Distal (>10kb) Multiome	419
chr19:6,515,952–6,517,331	74.9 kb	Distal (>10kb) Multiome	732
chr19:6,530,842–6,531,584	60.1 kb	Distal (>10kb) Multiome	640
chr19:6,551,766–6,552,224	39.1 kb	Distal (>10kb) Multiome	403
chr19:6,656,104–6,656,671	65.3 kb	Distal (>10kb) Multiome	10
chr19:6,661,103–6,661,799	70.4 kb	Distal (>10kb) Multiome	83
chr19:6,718,413–6,719,236	127.8 kb	Distal (>10kb) Multiome	284
chr19:6,729,971–6,731,015	139.5 kb	Distal (>10kb) Multiome	470
chr19:6,736,423–6,741,197	146.5 kb	Distal (>10kb) Multiome	1129
chr19:6,752,403–6,754,362	162.6 kb	Distal (>10kb) Multiome	886
chr19:6,767,097–6,768,193	176.5 kb	Distal (>10kb) Multiome	549

Genome Browser

Genomic view of the CD70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.