This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for CD48. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD48 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD48, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,539,925–160,540,644 | 171.5 kb | Distal (>10kb) Multiome | 479 | |
| chr1:160,619,659–160,620,443 | 91.7 kb | Distal (>10kb) Multiome | 187 | |
| chr1:160,651,647–160,653,226 | 59.3 kb | Distal (>10kb) Multiome | 296 | |
| chr1:160,658,117–160,659,135 | 53.3 kb | Distal (>10kb) Multiome | 111 | |
| chr1:160,665,307–160,666,295 | 46.1 kb | Distal (>10kb) Multiome | 417 | |
| chr1:160,674,985–160,675,879 | 36.2 kb | Distal (>10kb) Multiome | 258 | |
| chr1:160,681,274–160,681,823 | 30.2 kb | Distal (>10kb) Multiome | 237 | |
| chr1:160,910,331–160,911,177 | 198.8 kb | Distal (>10kb) Multiome | 97 | |
| chr1:160,947,055–160,947,669 | 235.6 kb | Distal (>10kb) Multiome | 35 | |
| chr1:160,948,561–160,949,851 | 237.6 kb | Distal (>10kb) Multiome | 173 |
Genomic view of the CD48 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.