CCT3
chaperonin containing TCP1 subunit 3 | Cctg, TRIC5

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010]

Member of: DE-1 Developmental clusters: GC4
Biological processes 33 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP-dependent protein folding chaperone (GO:0140662)RNA binding (GO:0003723)cell body (GO:0044297)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)extracellular exosome (GO:0070062)microtubule (GO:0005874)microtubule (GO:0005874)positive regulation of protein localization to Cajal body (GO:1904871)positive regulation of telomerase RNA localization to Cajal body (GO:1904874)positive regulation of telomere maintenance via telomerase (GO:0032212)positive regulation of telomere maintenance via telomerase (GO:0032212)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein stabilization (GO:0050821)protein stabilization (GO:0050821)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)zona pellucida receptor complex (GO:0002199)
Expression (TPM)
CCT3 — as a Regulated Gene

TFs regulating CCT3 0 TFs

Transcription factors with Perturb-seq knockdown data for CCT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CCT3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr1:156,052,923–156,055,358 283.4 kb Distal (>10kb) Multiome 1053
chr1:156,060,806–156,061,738 277.1 kb Distal (>10kb) Multiome 318
chr1:156,063,507–156,064,184 274.5 kb Distal (>10kb) Multiome 199
chr1:156,076,488–156,077,355 261.3 kb Distal (>10kb) Multiome 246
chr1:156,081,942–156,083,586 255.7 kb Distal (>10kb) Multiome 670
chr1:156,105,879–156,107,316 231.7 kb Distal (>10kb) Multiome 663
chr1:156,114,184–156,115,669 223.6 kb Distal (>10kb) Multiome 824
chr1:156,123,520–156,124,091 214.5 kb Distal (>10kb) Multiome 679
chr1:156,129,945–156,130,610 207.9 kb Distal (>10kb) Multiome 733
chr1:156,146,058–156,146,760 191.9 kb Distal (>10kb) Multiome 429
chr1:156,149,593–156,150,242 188.3 kb Distal (>10kb) Multiome 194
chr1:156,160,602–156,161,218 177.2 kb Distal (>10kb) Multiome 218
chr1:156,181,487–156,182,119 156.5 kb Distal (>10kb) Multiome 145
chr1:156,184,002–156,185,155 153.9 kb Distal (>10kb) Multiome 216
chr1:156,193,531–156,194,375 144.3 kb Distal (>10kb) Multiome 751
chr1:156,212,611–156,213,686 125.2 kb Distal (>10kb) Multiome 893
chr1:156,245,413–156,246,269 92.5 kb Distal (>10kb) Multiome 380
chr1:156,282,165–156,283,323 55.4 kb Distal (>10kb) Multiome 973
chr1:156,291,233–156,291,857 46.8 kb Distal (>10kb) Multiome 518
chr1:156,337,825–156,339,056 188 bp At TSS Multiome 836
chr1:156,356,873–156,357,393 18.8 kb Distal (>10kb) Multiome 506
chr1:156,368,893–156,369,552 30.9 kb Distal (>10kb) Multiome 529
chr1:156,420,712–156,422,291 83.5 kb Distal (>10kb) Multiome 569
chr1:156,429,277–156,430,847 91.6 kb Distal (>10kb) Multiome 231
chr1:156,432,112–156,432,986 94.3 kb Distal (>10kb) Multiome 50
chr1:156,439,076–156,440,265 101.7 kb Distal (>10kb) Multiome 264
chr1:156,456,348–156,457,982 118.4 kb Distal (>10kb) Multiome 1033
chr1:156,499,927–156,501,599 162.7 kb Distal (>10kb) Multiome 950
chr1:156,504,626–156,505,685 167.0 kb Distal (>10kb) Multiome 911
chr1:156,572,298–156,572,749 234.3 kb Distal (>10kb) Multiome 580
chr1:156,583,883–156,584,356 245.8 kb Distal (>10kb) Multiome 183
chr1:156,591,252–156,592,285 253.5 kb Distal (>10kb) Multiome 706
chr1:156,601,188–156,601,796 263.2 kb Distal (>10kb) Multiome 759
chr1:156,624,123–156,624,848 286.2 kb Distal (>10kb) Multiome 472

Genome Browser

Genomic view of the CCT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr1:156,042,923 – 156,634,848
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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