Transcription factors with Perturb-seq knockdown data for CCNT2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNT2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNT2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:134,717,803–134,719,682 | 199.6 kb | Distal (>10kb) Multiome | 356 | |
| chr2:134,751,756–134,752,551 | 166.6 kb | Distal (>10kb) Multiome | 87 | |
| chr2:134,771,271–134,772,068 | 147.2 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr2:134,772,446–134,773,111 | 145.8 kb | Distal (>10kb) Multiome HiCAR | 73 | |
| chr2:134,773,347–134,774,561 | 144.6 kb | Distal (>10kb) Multiome HiCAR | 237 | |
| chr2:134,774,748–134,775,767 | 143.4 kb | Distal (>10kb) Multiome HiCAR | 312 | |
| chr2:134,917,525–134,919,689 | 105 bp | At TSS Multiome | 1062 | |
| chr2:135,051,922–135,052,757 | 133.6 kb | Distal (>10kb) Multiome | 803 | |
| chr2:135,110,158–135,110,677 | 191.8 kb | Distal (>10kb) Multiome | 68 |
Genomic view of the CCNT2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.