The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CCNL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,115,769–1,117,022 | 283.1 kb | Distal (>10kb) Multiome | 743 | |
| chr1:1,157,424–1,158,362 | 241.8 kb | Distal (>10kb) Multiome | 575 | |
| chr1:1,200,907–1,201,739 | 197.9 kb | Distal (>10kb) Multiome | 430 | |
| chr1:1,231,448–1,233,390 | 167.2 kb | Distal (>10kb) Multiome | 884 | |
| chr1:1,273,333–1,274,645 | 125.4 kb | Distal (>10kb) Multiome | 779 | |
| chr1:1,293,434–1,294,454 | 105.4 kb | Distal (>10kb) Multiome | 234 | |
| chr1:1,307,375–1,310,219 | 91.0 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,324,278–1,325,394 | 74.6 kb | Distal (>10kb) Multiome | 735 | |
| chr1:1,348,716–1,350,027 | 49.8 kb | Distal (>10kb) Multiome | 539 | |
| chr1:1,353,403–1,354,425 | 45.4 kb | Distal (>10kb) Multiome | 276 | |
| chr1:1,374,767–1,375,798 | 24.0 kb | Distal (>10kb) Multiome | 1113 | |
| chr1:1,398,861–1,399,955 | 130 bp | At TSS Multiome | 879 | |
| chr1:1,406,992–1,407,823 | 8.0 kb | Proximal (<10kb) Multiome | 938 | |
| chr1:1,435,318–1,436,066 | 36.3 kb | Distal (>10kb) Multiome | 511 | |
| chr1:1,511,442–1,512,404 | 112.7 kb | Distal (>10kb) Multiome | 897 | |
| chr1:1,540,164–1,541,317 | 141.3 kb | Distal (>10kb) Multiome | 195 | |
| chr1:1,573,904–1,575,432 | 175.5 kb | Distal (>10kb) Multiome | 949 | |
| chr1:1,599,945–1,600,642 | 200.6 kb | Distal (>10kb) Multiome | 307 | |
| chr1:1,615,103–1,616,799 | 216.2 kb | Distal (>10kb) Multiome | 951 | |
| chr1:1,628,379–1,632,529 | 230.8 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 259.8 kb | Distal (>10kb) Multiome | 602 |
Genomic view of the CCNL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.