The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CCNC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:99,348,770–99,350,367 | 219.0 kb | Distal (>10kb) Multiome | 615 | |
| chr6:99,393,480–99,394,529 | 174.8 kb | Distal (>10kb) Multiome | 782 | |
| chr6:99,424,727–99,426,355 | 143.3 kb | Distal (>10kb) Multiome | 975 | |
| chr6:99,514,702–99,516,390 | 53.3 kb | Distal (>10kb) Multiome | 945 | |
| chr6:99,520,676–99,522,033 | 47.7 kb | Distal (>10kb) Multiome | 822 | |
| chr6:99,567,957–99,569,279 | 49 bp | At TSS Multiome | 1064 | |
| chr6:99,588,272–99,589,608 | 20.1 kb | Distal (>10kb) Multiome | 545 | |
| chr6:99,602,753–99,604,086 | 35.0 kb | Distal (>10kb) Multiome | 376 | |
| chr6:99,612,582–99,615,086 | 44.9 kb | Distal (>10kb) Multiome | 533 | |
| chr6:99,618,513–99,619,470 | 50.1 kb | Distal (>10kb) Multiome | 225 |
Genomic view of the CCNC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.