The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for CCNA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:121,696,158–121,697,590 | 126.9 kb | Distal (>10kb) Multiome | 831 | |
| chr4:121,711,374–121,712,252 | 112.1 kb | Distal (>10kb) Multiome | 592 | |
| chr4:121,749,014–121,749,684 | 74.5 kb | Distal (>10kb) Multiome | 138 | |
| chr4:121,764,589–121,765,761 | 58.8 kb | Distal (>10kb) Multiome | 279 | |
| chr4:121,800,778–121,801,755 | 22.5 kb | Distal (>10kb) Multiome | 866 | |
| chr4:121,822,774–121,824,390 | 88 bp | At TSS Multiome | 880 | |
| chr4:121,869,547–121,871,130 | 46.6 kb | Distal (>10kb) Multiome | 687 | |
| chr4:121,900,129–121,900,683 | 76.6 kb | Distal (>10kb) Multiome | 142 | |
| chr4:121,950,003–121,952,427 | 126.5 kb | Distal (>10kb) Multiome | 598 |
Genomic view of the CCNA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.