Predicted to be involved in cerebral cortex development. Predicted to act upstream of or within several processes, including Notch signaling pathway; establishment of cell polarity; and radial glial cell differentiation. Located in adherens junction and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC85C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC85C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC85C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:99,479,847–99,482,007 | 123.1 kb | Distal (>10kb) Multiome | 803 | |
| chr14:99,580,183–99,580,635 | 23.8 kb | Distal (>10kb) Multiome HiCAR | 170 | |
| chr14:99,598,907–99,599,138 | 5.1 kb | Proximal (<10kb) | 165 | |
| chr14:99,600,299–99,600,749 | 3.5 kb | Proximal (<10kb) | 80 | |
| chr14:99,602,979–99,605,771 | 225 bp | At TSS Multiome | 993 | |
| chr14:99,663,812–99,664,749 | 60.1 kb | Distal (>10kb) Multiome | 215 | |
| chr14:99,682,774–99,684,994 | 78.6 kb | Distal (>10kb) Multiome | 763 | |
| chr14:99,729,847–99,731,033 | 126.0 kb | Distal (>10kb) Multiome | 551 | |
| chr14:99,784,162–99,785,069 | 180.5 kb | Distal (>10kb) Multiome | 291 | |
| chr14:99,792,691–99,793,898 | 189.1 kb | Distal (>10kb) Multiome | 378 |
Genomic view of the CCDC85C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.