This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for CCDC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:59,708,672–59,710,741 | 196.7 kb | Distal (>10kb) Multiome | 600 | |
| chr10:59,847,061–59,847,658 | 59.1 kb | Distal (>10kb) Multiome | 103 | |
| chr10:59,905,191–59,907,242 | 105 bp | At TSS Multiome | 1011 | |
| chr10:59,907,971–59,908,967 | 2.0 kb | Proximal (<10kb) Multiome | 483 | |
| chr10:60,003,360–60,004,346 | 97.3 kb | Distal (>10kb) Multiome | 154 | |
| chr10:60,140,244–60,141,578 | 234.3 kb | Distal (>10kb) Multiome | 519 | |
| chr10:60,175,056–60,176,110 | 269.1 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the CCDC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.