Enables protein folding chaperone and ribosome binding activity. Involved in ERAD pathway; endoplasmic reticulum calcium ion homeostasis; and multi-pass transmembrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of multi-pass translocon complex and protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC47. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC47 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC47, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:63,476,359–63,478,095 | 296.3 kb | Distal (>10kb) Multiome | 520 | |
| chr17:63,478,783–63,479,370 | 294.5 kb | Distal (>10kb) Multiome | 419 | |
| chr17:63,522,589–63,523,803 | 250.4 kb | Distal (>10kb) Multiome | 705 | |
| chr17:63,549,660–63,551,443 | 223.3 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:63,600,715–63,601,423 | 172.7 kb | Distal (>10kb) Multiome | 1122 | |
| chr17:63,621,512–63,623,359 | 151.6 kb | Distal (>10kb) Multiome | 956 | |
| chr17:63,698,705–63,701,428 | 73.4 kb | Distal (>10kb) Multiome | 663 | |
| chr17:63,741,119–63,742,935 | 31.7 kb | Distal (>10kb) Multiome | 1057 | |
| chr17:63,773,179–63,774,727 | 169 bp | At TSS Multiome | 1169 | |
| chr17:63,775,530–63,775,783 | 1.9 kb | Proximal (<10kb) | 114 | |
| chr17:63,826,794–63,828,024 | 53.8 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:63,841,547–63,843,442 | 69.4 kb | Distal (>10kb) Multiome | 1203 | |
| chr17:63,848,836–63,849,566 | 75.6 kb | Distal (>10kb) Multiome | 658 | |
| chr17:63,960,119–63,962,604 | 188.3 kb | Distal (>10kb) Multiome | 445 | |
| chr17:63,998,051–63,998,826 | 224.8 kb | Distal (>10kb) Multiome | 408 |
Genomic view of the CCDC47 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.