Located in centriolar satellite. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC112. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC112 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC112, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,169,002–115,171,603 | 126.6 kb | Distal (>10kb) Multiome | 964 | |
| chr5:115,178,880–115,180,758 | 116.2 kb | Distal (>10kb) Multiome | 500 | |
| chr5:115,261,984–115,262,270 | 9.3 kb | Proximal (<10kb) | 120 | |
| chr5:115,262,382–115,263,400 | 33.8 kb | Distal (>10kb) Multiome | 905 | |
| chr5:115,295,823–115,297,287 | 23 bp | At TSS Multiome | 763 | |
| chr5:115,384,667–115,385,510 | 88.5 kb | Distal (>10kb) Multiome | 108 | |
| chr5:115,543,835–115,545,478 | 248.2 kb | Distal (>10kb) Multiome | 943 | |
| chr5:115,601,724–115,602,813 | 305.5 kb | Distal (>10kb) Multiome HiCAR | 542 |
Genomic view of the CCDC112 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.