The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for CAPN12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPN12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPN12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:38,452,620–38,453,510 | 291.0 kb | Distal (>10kb) Multiome | 355 | |
| chr19:38,506,710–38,507,745 | 236.9 kb | Distal (>10kb) Multiome | 369 | |
| chr19:38,514,956–38,515,568 | 228.9 kb | Distal (>10kb) Multiome | 404 | |
| chr19:38,565,090–38,565,701 | 178.8 kb | Distal (>10kb) Multiome | 164 | |
| chr19:38,595,857–38,597,322 | 147.8 kb | Distal (>10kb) Multiome | 478 | |
| chr19:38,617,752–38,619,569 | 125.2 kb | Distal (>10kb) Multiome | 835 | |
| chr19:38,647,137–38,648,653 | 96.6 kb | Distal (>10kb) Multiome | 856 | |
| chr19:38,666,103–38,666,668 | 77.9 kb | Distal (>10kb) Multiome | 317 | |
| chr19:38,683,677–38,684,144 | 60.5 kb | Distal (>10kb) Multiome | 678 | |
| chr19:38,729,757–38,729,964 | 5.5 kb | Proximal (<10kb) | 158 | |
| chr19:38,734,491–38,735,702 | 8.8 kb | Proximal (<10kb) Multiome | 338 | |
| chr19:38,735,981–38,737,634 | 7.1 kb | Proximal (<10kb) Multiome | 493 | |
| chr19:38,753,783–38,754,151 | 9.6 kb | Proximal (<10kb) | 21 | |
| chr19:38,754,913–38,755,455 | 11.0 kb | Distal (>10kb) Multiome | 12 | |
| chr19:38,831,191–38,832,119 | 87.7 kb | Distal (>10kb) Multiome HiCAR | 931 | |
| chr19:38,849,166–38,852,789 | 107.9 kb | Distal (>10kb) Multiome HiCAR | 1139 | |
| chr19:38,869,729–38,870,536 | 125.9 kb | Distal (>10kb) Multiome HiCAR | 350 | |
| chr19:38,899,267–38,900,530 | 155.7 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr19:38,930,044–38,931,363 | 186.6 kb | Distal (>10kb) Multiome | 889 | |
| chr19:38,949,549–38,950,582 | 205.7 kb | Distal (>10kb) Multiome | 330 | |
| chr19:38,975,192–38,976,859 | 232.6 kb | Distal (>10kb) Multiome | 846 | |
| chr19:38,995,916–38,996,388 | 252.0 kb | Distal (>10kb) Multiome | 144 | |
| chr19:39,030,958–39,033,042 | 287.4 kb | Distal (>10kb) Multiome | 763 |
Genomic view of the CAPN12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.