This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:17,167,353–17,167,906 | 226.1 kb | Distal (>10kb) Multiome | 251 | |
| chr6:17,200,410–17,200,969 | 193.0 kb | Distal (>10kb) Multiome | 168 | |
| chr6:17,280,275–17,282,527 | 112.7 kb | Distal (>10kb) Multiome | 573 | |
| chr6:17,393,134–17,394,567 | 117 bp | At TSS Multiome | 710 | |
| chr6:17,417,499–17,418,859 | 24.4 kb | Distal (>10kb) Multiome | 259 | |
| chr6:17,472,571–17,473,238 | 79.2 kb | Distal (>10kb) Multiome | 338 | |
| chr6:17,599,884–17,601,398 | 206.7 kb | Distal (>10kb) Multiome | 972 |
Genomic view of the CAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.