CAMSAP3

calmodulin regulated spectrin associated protein family member 3 | Nezha, PPP1R80, KIAA1543

Enables actin filament binding activity and microtubule minus-end binding activity. Involved in several processes, including microtubule cytoskeleton organization; regulation of organelle organization; and zonula adherens maintenance. Located in cytoplasm; microtubule cytoskeleton; and zonula adherens. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-5 Developmental clusters: GC6

Biological processes 50 terms

DNA binding (GO:0003677)DNA replication checkpoint signaling (GO:0000076)actin filament binding (GO:0051015)adherens junction (GO:0005912)axoneme (GO:0005930)axoneme (GO:0005930)calmodulin binding (GO:0005516)centrosome (GO:0005813)ciliary basal body (GO:0036064)ciliary basal body (GO:0036064)cilium movement (GO:0003341)cilium movement (GO:0003341)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)embryo development ending in birth or egg hatching (GO:0009792)embryo development ending in birth or egg hatching (GO:0009792)epithelial cell-cell adhesion (GO:0090136)establishment of epithelial cell apical/basal polarity (GO:0045198)establishment of epithelial cell apical/basal polarity (GO:0045198)establishment or maintenance of microtubule cytoskeleton polarity (GO:0030951)establishment or maintenance of microtubule cytoskeleton polarity (GO:0030951)microtubule anchoring (GO:0034453)microtubule binding (GO:0008017)microtubule cytoskeleton (GO:0015630)microtubule cytoskeleton organization (GO:0000226)microtubule cytoskeleton organization (GO:0000226)microtubule cytoskeleton organization (GO:0000226)microtubule minus-end (GO:0036449)microtubule minus-end (GO:0036449)microtubule minus-end binding (GO:0051011)microtubule minus-end binding (GO:0051011)motile cilium (GO:0031514)motile cilium (GO:0031514)neuron projection development (GO:0031175)protein binding (GO:0005515)protein transport along microtubule (GO:0098840)protein transport along microtubule (GO:0098840)regulation of Golgi organization (GO:1903358)regulation of cell migration (GO:0030334)regulation of focal adhesion assembly (GO:0051893)regulation of microtubule cytoskeleton organization (GO:0070507)regulation of microtubule polymerization (GO:0031113)regulation of microtubule polymerization (GO:0031113)regulation of organelle organization (GO:0033043)replication fork arrest (GO:0043111)replication fork protection complex (GO:0031298)spectrin binding (GO:0030507)zonula adherens (GO:0005915)zonula adherens maintenance (GO:0045218)

Expression (TPM)

TFs regulating CAMSAP3 0 TFs

Transcription factors with Perturb-seq knockdown data for CAMSAP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMSAP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CAMSAP3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMSAP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:7,394,774–7,395,629	200.8 kb	Distal (>10kb) Multiome	601
chr19:7,482,657–7,483,489	112.7 kb	Distal (>10kb) Multiome	201
chr19:7,488,712–7,489,463	106.8 kb	Distal (>10kb) Multiome	542
chr19:7,500,843–7,501,401	94.7 kb	Distal (>10kb) Multiome	556
chr19:7,505,850–7,507,270	89.3 kb	Distal (>10kb) Multiome	516
chr19:7,507,812–7,508,356	87.8 kb	Distal (>10kb) Multiome	168
chr19:7,522,263–7,523,208	73.3 kb	Distal (>10kb) Multiome	917
chr19:7,533,976–7,536,472	61.8 kb	Distal (>10kb) Multiome	882
chr19:7,550,673–7,551,762	44.5 kb	Distal (>10kb) Multiome	377
chr19:7,554,651–7,555,821	40.6 kb	Distal (>10kb) Multiome	224
chr19:7,595,485–7,596,417	76 bp	At TSS Multiome	405
chr19:7,629,285–7,629,891	33.8 kb	Distal (>10kb) Multiome	650
chr19:7,636,753–7,637,571	41.2 kb	Distal (>10kb) Multiome	689
chr19:7,680,480–7,681,546	84.9 kb	Distal (>10kb) Multiome	679
chr19:7,829,238–7,830,666	234.0 kb	Distal (>10kb) Multiome	621
chr19:7,853,168–7,853,781	257.6 kb	Distal (>10kb) Multiome	747
chr19:7,861,607–7,864,383	266.8 kb	Distal (>10kb) Multiome	348
chr19:7,868,454–7,870,252	273.6 kb	Distal (>10kb) Multiome	721
chr19:7,871,072–7,872,772	276.2 kb	Distal (>10kb) Multiome	487
chr19:7,873,962–7,875,061	278.8 kb	Distal (>10kb) Multiome	416
chr19:7,888,334–7,888,798	292.6 kb	Distal (>10kb) Multiome	509

Genome Browser

Genomic view of the CAMSAP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.