The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for CAMK2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMK2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMK2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:113,584,307–113,585,099 | 176.8 kb | Distal (>10kb) Multiome | 295 | |
| chr4:113,645,478–113,646,884 | 115.0 kb | Distal (>10kb) Multiome | 507 | |
| chr4:113,695,427–113,696,096 | 65.8 kb | Distal (>10kb) Multiome | 195 | |
| chr4:113,752,535–113,753,179 | 7.9 kb | Proximal (<10kb) | 88 | |
| chr4:113,753,385–113,753,552 | 7.5 kb | Proximal (<10kb) | 12 | |
| chr4:113,760,129–113,763,314 | 99 bp | At TSS Multiome | 1053 | |
| chr4:113,764,456–113,765,073 | 3.4 kb | Proximal (<10kb) | 97 | |
| chr4:113,978,461–113,980,695 | 218.1 kb | Distal (>10kb) Multiome | 481 |
Genomic view of the CAMK2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.