Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm. Predicted to be part of serine/threonine protein kinase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CAB39L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAB39L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAB39L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:49,184,188–49,185,149 | 259.3 kb | Distal (>10kb) Multiome | 84 | |
| chr13:49,218,368–49,219,071 | 225.3 kb | Distal (>10kb) Multiome | 51 | |
| chr13:49,219,748–49,221,361 | 223.8 kb | Distal (>10kb) Multiome | 441 | |
| chr13:49,247,525–49,248,779 | 196.1 kb | Distal (>10kb) Multiome | 752 | |
| chr13:49,280,990–49,281,662 | 162.7 kb | Distal (>10kb) Multiome | 111 | |
| chr13:49,443,422–49,445,325 | 78 bp | At TSS Multiome | 929 | |
| chr13:49,495,326–49,496,757 | 52.1 kb | Distal (>10kb) Multiome | 729 | |
| chr13:49,559,958–49,561,357 | 116.8 kb | Distal (>10kb) Multiome | 297 | |
| chr13:49,584,820–49,586,364 | 141.6 kb | Distal (>10kb) Multiome | 809 | |
| chr13:49,628,213–49,628,711 | 184.4 kb | Distal (>10kb) Multiome | 271 | |
| chr13:49,635,533–49,636,248 | 191.7 kb | Distal (>10kb) Multiome | 74 | |
| chr13:49,664,328–49,664,981 | 220.7 kb | Distal (>10kb) Multiome | 75 | |
| chr13:49,690,816–49,691,882 | 247.4 kb | Distal (>10kb) Multiome | 847 |
Genomic view of the CAB39L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.