Enables kinase binding activity and protein serine/threonine kinase activator activity. Involved in intracellular signal transduction; peptidyl-serine phosphorylation; and positive regulation of protein phosphorylation. Located in cytoplasm. Part of serine/threonine protein kinase complex. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and pancreatic cancer. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CAB39. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAB39 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAB39, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:230,712,242–230,714,378 | 1.2 kb | Proximal (<10kb) Multiome | 894 | |
| chr2:230,717,532–230,717,998 | 4.7 kb | Proximal (<10kb) | 109 | |
| chr2:230,849,764–230,850,557 | 137.3 kb | Distal (>10kb) Multiome | 238 | |
| chr2:230,864,158–230,866,508 | 152.0 kb | Distal (>10kb) Multiome | 798 | |
| chr2:230,870,556–230,871,541 | 158.2 kb | Distal (>10kb) Multiome | 223 | |
| chr2:230,902,219–230,902,930 | 189.8 kb | Distal (>10kb) Multiome | 248 | |
| chr2:230,987,027–230,987,549 | 274.5 kb | Distal (>10kb) Multiome | 571 |
Genomic view of the CAB39 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.