Involved in negative regulation of apoptotic process. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CAAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:26,682,826–26,683,655 | 209.6 kb | Distal (>10kb) Multiome | 130 | |
| chr9:26,891,915–26,893,136 | 180 bp | At TSS Multiome | 980 | |
| chr9:26,893,164–26,893,697 | 361 bp | At TSS | 123 | |
| chr9:26,946,640–26,948,029 | 54.5 kb | Distal (>10kb) Multiome | 852 | |
| chr9:26,955,897–26,957,142 | 63.6 kb | Distal (>10kb) Multiome | 646 | |
| chr9:26,974,839–26,976,887 | 83.5 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the CAAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.