Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CA14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CA14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CA14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,010,143–150,011,088 | 247.1 kb | Distal (>10kb) Multiome | 961 | |
| chr1:150,066,903–150,067,886 | 190.1 kb | Distal (>10kb) Multiome | 986 | |
| chr1:150,149,493–150,150,439 | 107.7 kb | Distal (>10kb) Multiome | 448 | |
| chr1:150,162,838–150,163,636 | 94.5 kb | Distal (>10kb) Multiome | 550 | |
| chr1:150,213,532–150,214,095 | 44.0 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,234,435–150,235,519 | 23.0 kb | Distal (>10kb) Multiome | 725 | |
| chr1:150,235,635–150,236,696 | 21.5 kb | Distal (>10kb) Multiome | 905 | |
| chr1:150,255,443–150,256,199 | 2.0 kb | Proximal (<10kb) Multiome | 441 | |
| chr1:150,256,563–150,257,324 | 723 bp | At TSS Multiome | 223 | |
| chr1:150,257,589–150,258,594 | 364 bp | At TSS Multiome | 233 | |
| chr1:150,259,728–150,260,778 | 2.4 kb | Proximal (<10kb) Multiome | 362 | |
| chr1:150,268,574–150,269,453 | 11.3 kb | Distal (>10kb) Multiome | 785 | |
| chr1:150,281,629–150,283,038 | 24.7 kb | Distal (>10kb) Multiome | 503 | |
| chr1:150,293,680–150,294,144 | 36.1 kb | Distal (>10kb) Multiome | 755 | |
| chr1:150,313,761–150,314,506 | 56.3 kb | Distal (>10kb) Multiome | 108 | |
| chr1:150,321,137–150,321,825 | 63.7 kb | Distal (>10kb) Multiome | 806 | |
| chr1:150,363,368–150,364,980 | 106.2 kb | Distal (>10kb) Multiome | 971 | |
| chr1:150,487,154–150,487,710 | 229.6 kb | Distal (>10kb) Multiome | 929 | |
| chr1:150,515,085–150,516,227 | 257.9 kb | Distal (>10kb) Multiome | 781 | |
| chr1:150,548,849–150,549,823 | 291.5 kb | Distal (>10kb) Multiome | 620 |
Genomic view of the CA14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.