Located in plasma membrane. Implicated in hypotrichosis 15. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C3orf52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C3orf52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C3orf52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:111,858,752–111,861,061 | 225.7 kb | Distal (>10kb) Multiome | 807 | |
| chr3:111,978,499–111,979,684 | 107.4 kb | Distal (>10kb) Multiome | 800 | |
| chr3:111,998,552–111,999,758 | 87.2 kb | Distal (>10kb) Multiome | 325 | |
| chr3:112,084,841–112,085,276 | 1.1 kb | Proximal (<10kb) | 86 | |
| chr3:112,085,739–112,087,192 | 33 bp | At TSS Multiome | 690 | |
| chr3:112,092,654–112,093,131 | 6.3 kb | Proximal (<10kb) | 89 | |
| chr3:112,126,419–112,126,878 | 40.3 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 50.7 kb | Distal (>10kb) Multiome | 233 | |
| chr3:112,293,399–112,294,560 | 207.5 kb | Distal (>10kb) Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 217.0 kb | Distal (>10kb) Multiome | 204 | |
| chr3:112,332,830–112,333,873 | 247.1 kb | Distal (>10kb) Multiome | 281 |
Genomic view of the C3orf52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.