C3

C3

complement C3 | ARMD9, C3a, C3b, CPAMD1

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]

Developmental clusters: GC6

Biological processes 75 terms

B cell activation (GO:0042113)C5L2 anaphylatoxin chemotactic receptor binding (GO:0031715)G protein-coupled receptor signaling pathway (GO:0007186)amyloid-beta clearance (GO:0097242)amyloid-beta clearance (GO:0097242)antigen binding (GO:0003823)azurophil granule lumen (GO:0035578)blood microparticle (GO:0072562)cell surface (GO:0009986)chemokine activity (GO:0008009)classical-complement-pathway C3/C5 convertase complex (GO:0005601)complement activation (GO:0006956)complement activation (GO:0006956)complement activation (GO:0006956)complement activation (GO:0006956)complement activation (GO:0006956)complement activation, GZMK pathway (GO:0160257)complement activation, alternative pathway (GO:0006957)complement activation, classical pathway (GO:0006958)complement activation, lectin pathway (GO:0001867)complement receptor mediated signaling pathway (GO:0002430)complement-mediated synapse pruning (GO:0150062)complement-mediated synapse pruning (GO:0150062)cytoplasmic side of Golgi membrane (GO:0098548)cytoplasmic side of Golgi membrane (GO:0098548)endopeptidase inhibitor activity (GO:0004866)endoplasmic reticulum lumen (GO:0005788)extracellular exosome (GO:0070062)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)immune response (GO:0006955)inflammatory response (GO:0006954)leukocyte chemotaxis (GO:0030595)neuron remodeling (GO:0016322)neuron remodeling (GO:0016322)opsonization (GO:0008228)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of D-glucose transmembrane transport (GO:0010828)positive regulation of G protein-coupled receptor signaling pathway (GO:0045745)positive regulation of activation of membrane attack complex (GO:0001970)positive regulation of angiogenesis (GO:0045766)positive regulation of apoptotic cell clearance (GO:2000427)positive regulation of apoptotic cell clearance (GO:2000427)positive regulation of immune response (GO:0050778)positive regulation of lipid storage (GO:0010884)positive regulation of opsonization (GO:1903028)positive regulation of opsonization (GO:1903028)positive regulation of phagocytosis (GO:0050766)positive regulation of phagocytosis, engulfment (GO:0060100)positive regulation of phagocytosis, engulfment (GO:0060100)positive regulation of protein phosphorylation (GO:0001934)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of receptor-mediated endocytosis (GO:0048260)positive regulation of vascular endothelial growth factor production (GO:0010575)protein binding (GO:0005515)protein-containing complex (GO:0032991)proteolysis (GO:0006508)receptor ligand activity (GO:0048018)regulation of complement activation (GO:0030449)regulation of complement activation, alternative pathway (GO:0030451)regulation of triglyceride biosynthetic process (GO:0010866)response to other organism (GO:0051707)secretory granule lumen (GO:0034774)signal transduction (GO:0007165)signaling receptor binding (GO:0005102)symbiont cell surface (GO:0106139)vertebrate eye-specific patterning (GO:0150064)vertebrate eye-specific patterning (GO:0150064)

Expression (TPM)

TFs regulating C3 0 TFs

Transcription factors with Perturb-seq knockdown data for C3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to C3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr19:6,458,960–6,460,940	270.2 kb	Distal (>10kb) Multiome	859
	chr19:6,463,863–6,464,838	266.3 kb	Distal (>10kb) Multiome	526
	chr19:6,470,903–6,471,589	259.3 kb	Distal (>10kb) Multiome	26
	chr19:6,475,386–6,477,353	254.0 kb	Distal (>10kb) Multiome	419
	chr19:6,515,952–6,517,331	214.3 kb	Distal (>10kb) Multiome HiCAR	732
	chr19:6,530,842–6,531,584	199.6 kb	Distal (>10kb) Multiome	640
	chr19:6,551,766–6,552,224	178.5 kb	Distal (>10kb) Multiome	403
	chr19:6,656,104–6,656,671	74.1 kb	Distal (>10kb) Multiome	10
	chr19:6,661,103–6,661,799	69.0 kb	Distal (>10kb) Multiome	83
	chr19:6,710,642–6,711,089	at TSS	At TSS	153
	chr19:6,718,413–6,719,236	11.6 kb	Distal (>10kb) Multiome	284
	chr19:6,729,971–6,731,015	56 bp	At TSS Multiome	470
	chr19:6,736,423–6,741,197	7.1 kb	Proximal (<10kb) Multiome	1129
	chr19:6,752,403–6,754,362	23.2 kb	Distal (>10kb) Multiome	886
	chr19:6,767,097–6,768,193	37.1 kb	Distal (>10kb) Multiome	549

Genome Browser

Genomic view of the C3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.