Transcription factors with Perturb-seq knockdown data for C2orf74-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf74-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf74-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:60,853,117–60,853,733 | 291.6 kb | Distal (>10kb) Multiome | 48 | |
| chr2:60,880,748–60,882,118 | 263.5 kb | Distal (>10kb) Multiome | 991 | |
| chr2:61,016,845–61,018,378 | 127.5 kb | Distal (>10kb) Multiome | 1133 | |
| chr2:61,065,384–61,066,693 | 79.1 kb | Distal (>10kb) Multiome | 856 | |
| chr2:61,144,728–61,145,208 | at TSS | At TSS | 512 | |
| chr2:61,157,943–61,158,813 | 13.6 kb | Distal (>10kb) Multiome | 49 | |
| chr2:61,165,843–61,166,373 | 21.2 kb | Distal (>10kb) Multiome | 88 | |
| chr2:61,176,826–61,178,378 | 32.3 kb | Distal (>10kb) Multiome | 1042 |
Genomic view of the C2orf74-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.