Predicted to enable cytokine activity. Involved in positive regulation of cytokine production and positive regulation of signal transduction. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C1QTNF4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C1QTNF4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C1QTNF4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:47,354,896–47,355,720 | 239.0 kb | Distal (>10kb) Multiome | 670 | |
| chr11:47,399,791–47,400,763 | 194.1 kb | Distal (>10kb) Multiome | 450 | |
| chr11:47,407,671–47,409,059 | 186.0 kb | Distal (>10kb) Multiome | 986 | |
| chr11:47,425,998–47,427,263 | 167.9 kb | Distal (>10kb) Multiome | 879 | |
| chr11:47,508,005–47,509,036 | 85.9 kb | Distal (>10kb) Multiome | 73 | |
| chr11:47,552,255–47,553,700 | 41.2 kb | Distal (>10kb) Multiome | 834 | |
| chr11:47,564,988–47,566,330 | 28.8 kb | Distal (>10kb) Multiome | 842 | |
| chr11:47,578,427–47,579,510 | 15.5 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:47,589,692–47,590,847 | 4.1 kb | Proximal (<10kb) Multiome | 161 | |
| chr11:47,594,122–47,594,733 | 68 bp | At TSS Multiome | 153 | |
| chr11:47,598,993–47,599,885 | 5.0 kb | Proximal (<10kb) Multiome | 67 | |
| chr11:47,642,000–47,643,006 | 48.2 kb | Distal (>10kb) Multiome | 973 | |
| chr11:47,714,892–47,715,563 | 120.9 kb | Distal (>10kb) Multiome | 607 | |
| chr11:47,766,463–47,768,105 | 173.1 kb | Distal (>10kb) Multiome | 961 | |
| chr11:47,847,845–47,848,997 | 254.0 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the C1QTNF4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.