Transcription factors with Perturb-seq knockdown data for C13orf42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C13orf42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C13orf42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:50,909,544–50,910,786 | 262.5 kb | Distal (>10kb) Multiome | 827 | |
| chr13:51,101,590–51,102,215 | 70.6 kb | Distal (>10kb) Multiome | 123 | |
| chr13:51,122,652–51,123,430 | 49.3 kb | Distal (>10kb) Multiome | 298 | |
| chr13:51,125,567–51,126,048 | 46.6 kb | Distal (>10kb) Multiome | 224 | |
| chr13:51,146,222–51,147,378 | 25.6 kb | Distal (>10kb) Multiome | 79 | |
| chr13:51,147,892–51,149,246 | 23.9 kb | Distal (>10kb) Multiome | 319 | |
| chr13:51,169,207–51,170,289 | 2.5 kb | Proximal (<10kb) Multiome | 174 | |
| chr13:51,171,477–51,171,724 | 663 bp | At TSS | 3 | |
| chr13:51,175,033–51,175,343 | 2.6 kb | Proximal (<10kb) | 21 | |
| chr13:51,178,352–51,178,770 | 6.0 kb | Proximal (<10kb) | 16 | |
| chr13:51,221,124–51,223,194 | 49.8 kb | Distal (>10kb) Multiome HiCAR | 488 | |
| chr13:51,243,717–51,244,186 | 71.5 kb | Distal (>10kb) Multiome | 185 | |
| chr13:51,244,496–51,245,455 | 72.8 kb | Distal (>10kb) Multiome | 117 | |
| chr13:51,303,027–51,303,676 | 130.9 kb | Distal (>10kb) Multiome | 130 | |
| chr13:51,451,249–51,454,202 | 279.4 kb | Distal (>10kb) Multiome | 1037 |
Genomic view of the C13orf42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.