Transcription factors with Perturb-seq knockdown data for C12orf75. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C12orf75 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C12orf75, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:105,083,642–105,085,161 | 246.1 kb | Distal (>10kb) Multiome | 490 | |
| chr12:105,107,164–105,108,312 | 222.9 kb | Distal (>10kb) Multiome | 1033 | |
| chr12:105,235,605–105,236,419 | 94.6 kb | Distal (>10kb) Multiome | 802 | |
| chr12:105,330,237–105,331,332 | 24 bp | At TSS Multiome | 497 | |
| chr12:105,331,909–105,332,183 | 1.3 kb | Proximal (<10kb) | 95 | |
| chr12:105,459,868–105,460,332 | 129.4 kb | Distal (>10kb) Multiome | 58 |
Genomic view of the C12orf75 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.