Enables cadherin binding activity. Involved in regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BZW2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BZW2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BZW2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:15,053,852–15,055,000 | 1591.7 kb | Distal (>10kb) Multiome HiCAR | 86 | |
| chr7:16,420,192–16,422,117 | 225.1 kb | Distal (>10kb) Multiome | 1014 | |
| chr7:16,511,401–16,512,647 | 134.0 kb | Distal (>10kb) Multiome | 110 | |
| chr7:16,587,596–16,588,471 | 58.2 kb | Distal (>10kb) Multiome | 148 | |
| chr7:16,638,453–16,639,115 | 7.0 kb | Proximal (<10kb) | 47 | |
| chr7:16,644,616–16,647,076 | 219 bp | At TSS Multiome | 1028 | |
| chr7:16,648,489–16,648,818 | 2.3 kb | Proximal (<10kb) | 128 | |
| chr7:16,753,299–16,754,826 | 107.6 kb | Distal (>10kb) Multiome | 780 | |
| chr7:16,851,810–16,852,609 | 206.0 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the BZW2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.