Enables identical protein binding activity. Predicted to be involved in cerebral cortex development and dendrite morphogenesis. Predicted to be located in nucleus. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BTBD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BTBD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BTBD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:11,602,685–11,604,041 | 287.4 kb | Distal (>10kb) Multiome | 186 | |
| chr20:11,695,968–11,697,783 | 193.5 kb | Distal (>10kb) Multiome | 155 | |
| chr20:11,890,303–11,892,721 | 30 bp | At TSS Multiome | 843 | |
| chr20:11,979,409–11,980,041 | 88.9 kb | Distal (>10kb) Multiome | 59 | |
| chr20:11,993,831–11,994,802 | 103.5 kb | Distal (>10kb) Multiome | 208 |
Genomic view of the BTBD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.