Enables protein phosphatase 2A binding activity and protein phosphatase inhibitor activity. Involved in mitotic sister chromatid biorientation; mitotic sister chromatid cohesion, centromeric; and protein localization to chromosome, centromeric region. Located in centrosome; spindle microtubule; and spindle pole. Part of Set1C/COMPASS complex and outer kinetochore. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:173,327,090–173,330,477 | 286.8 kb | Distal (>10kb) Multiome | 1064 | |
| chr5:173,615,977–173,617,113 | 141 bp | At TSS Multiome | 845 | |
| chr5:173,653,855–173,654,363 | 37.5 kb | Distal (>10kb) Multiome | 34 | |
| chr5:173,887,593–173,889,015 | 271.5 kb | Distal (>10kb) Multiome | 862 | |
| chr5:173,972,772–173,973,892 | 356.8 kb | Distal (>10kb) Multiome HiCAR | 508 | |
| chr5:174,311,542–174,312,385 | 695.5 kb | Distal (>10kb) Multiome HiCAR | 367 | |
| chr5:174,327,387–174,327,868 | 711.0 kb | Distal (>10kb) Multiome HiCAR | 343 |
Genomic view of the BOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.