This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for BMP7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMP7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMP7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:57,002,615–57,003,823 | 263.4 kb | Distal (>10kb) Multiome | 200 | |
| chr20:57,089,540–57,090,158 | 176.8 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr20:57,231,910–57,232,397 | 34.5 kb | Distal (>10kb) Multiome | 241 | |
| chr20:57,263,861–57,265,018 | 2.2 kb | Proximal (<10kb) Multiome | 521 | |
| chr20:57,265,156–57,267,217 | 14 bp | At TSS Multiome | 462 | |
| chr20:57,323,005–57,323,752 | 56.6 kb | Distal (>10kb) Multiome | 226 | |
| chr20:57,350,979–57,351,567 | 84.6 kb | Distal (>10kb) Multiome | 833 | |
| chr20:57,389,119–57,389,876 | 122.8 kb | Distal (>10kb) Multiome | 590 | |
| chr20:57,390,113–57,392,016 | 124.7 kb | Distal (>10kb) Multiome | 692 |
Genomic view of the BMP7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.