This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008]
Transcription factors with Perturb-seq knockdown data for BMP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BMP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BMP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:20,233,433–20,235,922 | 1930.5 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr8:21,918,240–21,920,671 | 245.6 kb | Distal (>10kb) Multiome | 727 | |
| chr8:22,009,978–22,010,924 | 154.8 kb | Distal (>10kb) Multiome | 885 | |
| chr8:22,024,029–22,025,514 | 140.0 kb | Distal (>10kb) Multiome | 508 | |
| chr8:22,036,665–22,037,480 | 128.3 kb | Distal (>10kb) Multiome | 457 | |
| chr8:22,039,647–22,043,111 | 125.2 kb | Distal (>10kb) Multiome | 407 | |
| chr8:22,047,856–22,051,849 | 116.0 kb | Distal (>10kb) Multiome | 566 | |
| chr8:22,052,727–22,057,283 | 111.3 kb | Distal (>10kb) Multiome | 541 | |
| chr8:22,066,266–22,067,293 | 98.4 kb | Distal (>10kb) Multiome | 612 | |
| chr8:22,069,764–22,070,311 | 95.2 kb | Distal (>10kb) Multiome | 85 | |
| chr8:22,089,006–22,089,746 | 76.1 kb | Distal (>10kb) Multiome | 562 | |
| chr8:22,095,301–22,095,802 | 69.7 kb | Distal (>10kb) Multiome | 199 | |
| chr8:22,108,625–22,110,515 | 55.7 kb | Distal (>10kb) Multiome | 907 | |
| chr8:22,129,779–22,131,071 | 34.8 kb | Distal (>10kb) Multiome | 440 | |
| chr8:22,137,231–22,137,850 | 27.7 kb | Distal (>10kb) Multiome | 531 | |
| chr8:22,140,995–22,142,545 | 23.3 kb | Distal (>10kb) Multiome | 753 | |
| chr8:22,156,517–22,157,091 | 8.4 kb | Proximal (<10kb) Multiome HiCAR | 215 | |
| chr8:22,164,354–22,165,830 | 225 bp | At TSS Multiome | 672 | |
| chr8:22,176,636–22,177,193 | 11.8 kb | Distal (>10kb) Multiome | 91 | |
| chr8:22,188,487–22,189,031 | 23.6 kb | Distal (>10kb) Multiome | 334 | |
| chr8:22,244,388–22,245,751 | 79.9 kb | Distal (>10kb) Multiome | 1013 | |
| chr8:22,275,120–22,276,011 | 110.1 kb | Distal (>10kb) Multiome | 195 | |
| chr8:22,365,087–22,366,071 | 200.3 kb | Distal (>10kb) Multiome | 444 | |
| chr8:22,366,837–22,368,383 | 202.0 kb | Distal (>10kb) Multiome | 859 | |
| chr8:22,440,466–22,441,769 | 275.8 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the BMP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.