This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Transcription factors with Perturb-seq knockdown data for BEX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BEX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BEX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,101,365–103,102,296 | 209.1 kb | Distal (>10kb) Multiome | 252 | |
| chrX:103,214,792–103,216,027 | 95.9 kb | Distal (>10kb) Multiome | 433 | |
| chrX:103,254,119–103,255,539 | 55.6 kb | Distal (>10kb) Multiome | 553 | |
| chrX:103,310,557–103,311,346 | 24 bp | At TSS Multiome | 289 | |
| chrX:103,376,152–103,376,747 | 65.4 kb | Distal (>10kb) Multiome | 356 | |
| chrX:103,431,896–103,432,874 | 121.4 kb | Distal (>10kb) Multiome | 6 | |
| chrX:103,607,566–103,608,355 | 297.0 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the BEX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.