BCL7C
BAF chromatin remodeling complex subunit BCL7C | SMARCJ3

This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Member of: DE-1 DE-1.13 Developmental clusters: GC6
Biological processes 16 terms
SWI/SNF complex (GO:0016514)SWI/SNF complex (GO:0016514)chromatin (GO:0000785)chromatin remodeling (GO:0006338)negative regulation of cell differentiation (GO:0045596)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)positive regulation of cell population proliferation (GO:0008284)positive regulation of double-strand break repair (GO:2000781)positive regulation of stem cell population maintenance (GO:1902459)protein binding (GO:0005515)regulation of G0 to G1 transition (GO:0070316)regulation of G1/S transition of mitotic cell cycle (GO:2000045)regulation of mitotic metaphase/anaphase transition (GO:0030071)regulation of nucleotide-excision repair (GO:2000819)regulation of transcription by RNA polymerase II (GO:0006357)
Expression (TPM)
BCL7C — as a Regulated Gene

TFs regulating BCL7C 0 TFs

Transcription factors with Perturb-seq knockdown data for BCL7C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL7C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to BCL7C

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL7C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:30,609,586–30,610,748 283.8 kb Distal (>10kb) Multiome 1030
chr16:30,634,070–30,634,986 259.8 kb Distal (>10kb) Multiome 907
chr16:30,650,029–30,651,831 243.5 kb Distal (>10kb) Multiome 992
chr16:30,657,638–30,659,894 235.9 kb Distal (>10kb) Multiome 1053
chr16:30,677,814–30,678,622 216.0 kb Distal (>10kb) Multiome 177
chr16:30,697,755–30,699,614 195.1 kb Distal (>10kb) Multiome 1153
chr16:30,747,864–30,748,943 145.8 kb Distal (>10kb) Multiome 824
chr16:30,761,380–30,762,606 132.0 kb Distal (>10kb) Multiome HiCAR 885
chr16:30,774,965–30,776,186 118.7 kb Distal (>10kb) Multiome 1025
chr16:30,786,385–30,788,019 107.0 kb Distal (>10kb) Multiome HiCAR 885
chr16:30,805,468–30,806,187 88.5 kb Distal (>10kb) Multiome 969
chr16:30,814,045–30,814,733 79.7 kb Distal (>10kb) Multiome HiCAR 995
chr16:30,841,062–30,841,882 52.6 kb Distal (>10kb) Multiome HiCAR 49
chr16:30,874,866–30,875,643 18.9 kb Distal (>10kb) Multiome 1108
chr16:30,893,485–30,894,587 24 bp At TSS Multiome 950
chr16:30,895,854–30,897,426 2.9 kb Proximal (<10kb) Multiome 822
chr16:30,901,969–30,902,794 8.2 kb Proximal (<10kb) Multiome 579
chr16:30,921,611–30,925,097 29.2 kb Distal (>10kb) Multiome 1132
chr16:30,927,705–30,928,596 34.0 kb Distal (>10kb) Multiome 274
chr16:30,941,803–30,942,254 47.9 kb Distal (>10kb) Multiome 507
chr16:30,947,471–30,950,635 56.0 kb Distal (>10kb) Multiome 1066
chr16:30,953,370–30,954,135 59.6 kb Distal (>10kb) Multiome 499
chr16:30,956,960–30,958,498 63.5 kb Distal (>10kb) Multiome 1022
chr16:30,984,837–30,985,709 91.0 kb Distal (>10kb) Multiome 787
chr16:30,996,877–30,998,001 103.2 kb Distal (>10kb) Multiome 759
chr16:31,010,379–31,011,032 116.5 kb Distal (>10kb) Multiome 117
chr16:31,032,789–31,034,448 139.3 kb Distal (>10kb) Multiome 1047
chr16:31,041,996–31,042,665 148.1 kb Distal (>10kb) Multiome 213
chr16:31,072,597–31,074,957 179.3 kb Distal (>10kb) Multiome 1167
chr16:31,094,132–31,095,139 200.6 kb Distal (>10kb) Multiome 933
chr16:31,108,209–31,108,826 214.2 kb Distal (>10kb) Multiome 733
chr16:31,117,128–31,118,265 223.6 kb Distal (>10kb) Multiome 929
chr16:31,134,682–31,136,040 241.5 kb Distal (>10kb) Multiome 450
chr16:31,138,695–31,139,457 244.9 kb Distal (>10kb) Multiome 413
chr16:31,141,455–31,143,270 248.2 kb Distal (>10kb) Multiome 856
chr16:31,148,229–31,148,775 254.2 kb Distal (>10kb) Multiome 209
chr16:31,179,340–31,181,495 285.8 kb Distal (>10kb) Multiome 1179

Genome Browser

Genomic view of the BCL7C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:30,599,586 – 31,191,495
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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