Enables histone binding activity. Contributes to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of transcription by RNA polymerase I; and rDNA heterochromatin formation. Predicted to act upstream of or within heterochromatin formation. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for BAZ2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAZ2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAZ2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:56,333,366–56,334,588 | 296.3 kb | Distal (>10kb) Multiome | 853 | |
| chr12:56,359,808–56,360,881 | 270.0 kb | Distal (>10kb) Multiome | 860 | |
| chr12:56,448,848–56,449,756 | 181.0 kb | Distal (>10kb) Multiome | 920 | |
| chr12:56,468,239–56,468,840 | 161.8 kb | Distal (>10kb) Multiome | 907 | |
| chr12:56,487,633–56,488,590 | 142.0 kb | Distal (>10kb) Multiome | 784 | |
| chr12:56,629,725–56,630,674 | 42 bp | At TSS Multiome | 759 | |
| chr12:56,632,332–56,632,687 | 2.0 kb | Proximal (<10kb) | 249 | |
| chr12:56,633,838–56,637,505 | 4.1 kb | Proximal (<10kb) Multiome | 1037 | |
| chr12:56,645,530–56,646,466 | 15.8 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr12:56,687,276–56,689,898 | 59.3 kb | Distal (>10kb) Multiome | 1162 | |
| chr12:56,724,695–56,725,713 | 95.0 kb | Distal (>10kb) Multiome | 972 | |
| chr12:56,751,814–56,752,566 | 122.0 kb | Distal (>10kb) Multiome | 765 | |
| chr12:57,546,771–57,547,419 | 916.9 kb | Distal (>10kb) Multiome HiCAR | 623 | |
| chr12:57,549,654–57,550,343 | 919.7 kb | Distal (>10kb) Multiome HiCAR | 366 |
Genomic view of the BAZ2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.