The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for BAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:33,000,845–33,002,021 | 263.1 kb | Distal (>10kb) Multiome | 802 | |
| chr9:33,024,523–33,026,243 | 239.4 kb | Distal (>10kb) Multiome | 972 | |
| chr9:33,044,108–33,044,981 | 220.2 kb | Distal (>10kb) Multiome | 451 | |
| chr9:33,076,221–33,076,965 | 188.0 kb | Distal (>10kb) Multiome | 804 | |
| chr9:33,166,320–33,168,338 | 97.3 kb | Distal (>10kb) Multiome | 849 | |
| chr9:33,171,750–33,173,178 | 92.1 kb | Distal (>10kb) Multiome | 359 | |
| chr9:33,264,068–33,265,475 | 91 bp | At TSS Multiome | 790 | |
| chr9:33,267,199–33,267,770 | 2.8 kb | Proximal (<10kb) Multiome | 106 | |
| chr9:33,290,056–33,291,152 | 25.8 kb | Distal (>10kb) Multiome | 1075 | |
| chr9:33,381,203–33,381,714 | 116.8 kb | Distal (>10kb) Multiome | 134 | |
| chr9:33,415,341–33,415,979 | 151.0 kb | Distal (>10kb) Multiome | 774 | |
| chr9:33,447,056–33,448,058 | 182.9 kb | Distal (>10kb) Multiome | 547 | |
| chr9:33,452,742–33,453,295 | 188.3 kb | Distal (>10kb) Multiome | 374 | |
| chr9:33,473,593–33,474,250 | 209.3 kb | Distal (>10kb) Multiome | 635 | |
| chr9:33,515,277–33,515,972 | 250.8 kb | Distal (>10kb) Multiome | 49 | |
| chr9:33,523,393–33,524,316 | 259.0 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the BAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.