This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for BABAM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BABAM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BABAM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:27,628,534–27,629,380 | 261.8 kb | Distal (>10kb) Multiome | 828 | |
| chr2:27,663,338–27,664,216 | 227.0 kb | Distal (>10kb) Multiome | 1035 | |
| chr2:27,681,105–27,682,049 | 209.2 kb | Distal (>10kb) Multiome | 85 | |
| chr2:27,715,293–27,715,981 | 174.8 kb | Distal (>10kb) Multiome | 346 | |
| chr2:27,735,279–27,736,049 | 155.2 kb | Distal (>10kb) Multiome | 395 | |
| chr2:27,752,465–27,753,359 | 137.9 kb | Distal (>10kb) Multiome | 577 | |
| chr2:27,771,346–27,772,271 | 119.0 kb | Distal (>10kb) Multiome | 941 | |
| chr2:27,889,901–27,891,358 | 172 bp | At TSS Multiome | 1000 |
Genomic view of the BABAM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.