B3GAT3
beta-1,3-glucuronyltransferase 3 | GlcAT-I

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. A pseudogene of this gene has been identified on chromosome 3. [provided by RefSeq, Dec 2013]

Member of: DE-1
Biological processes 34 terms
Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)carbohydrate metabolic process (GO:0005975)chondroitin sulfate proteoglycan biosynthetic process (GO:0050650)chondroitin sulfate proteoglycan biosynthetic process (GO:0050650)chondroitin sulfate proteoglycan biosynthetic process (GO:0050650)cis-Golgi network (GO:0005801)cis-Golgi network (GO:0005801)dermatan sulfate proteoglycan biosynthetic process (GO:0050651)dermatan sulfate proteoglycan biosynthetic process (GO:0050651)extracellular exosome (GO:0070062)galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018)galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018)galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018)galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018)galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity (GO:0015018)glucuronosyltransferase activity (GO:0015020)glucuronosyltransferase activity (GO:0015020)glycosaminoglycan biosynthetic process (GO:0006024)glycosaminoglycan biosynthetic process (GO:0006024)glycosaminoglycan biosynthetic process (GO:0006024)glycosaminoglycan biosynthetic process (GO:0006024)heparan sulfate proteoglycan biosynthetic process (GO:0015012)heparan sulfate proteoglycan biosynthetic process (GO:0015012)membrane (GO:0016020)membrane (GO:0016020)membrane (GO:0016020)positive regulation of catalytic activity (GO:0043085)positive regulation of intracellular protein transport (GO:0090316)protein binding (GO:0005515)protein phosphatase activator activity (GO:0072542)
Expression (TPM)
B3GAT3 — as a Regulated Gene

TFs regulating B3GAT3 0 TFs

Transcription factors with Perturb-seq knockdown data for B3GAT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = B3GAT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to B3GAT3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of B3GAT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr11:62,337,140–62,338,142 284.5 kb Distal (>10kb) Multiome 611
chr11:62,382,190–62,383,008 239.4 kb Distal (>10kb) Multiome 36
chr11:62,460,403–62,461,004 161.2 kb Distal (>10kb) Multiome 20
chr11:62,508,289–62,508,878 113.4 kb Distal (>10kb) Multiome 499
chr11:62,542,658–62,543,488 79.0 kb Distal (>10kb) Multiome 537
chr11:62,545,051–62,547,562 74.9 kb Distal (>10kb) Multiome 889
chr11:62,553,213–62,553,741 68.6 kb Distal (>10kb) Multiome 489
chr11:62,555,905–62,556,742 65.7 kb Distal (>10kb) Multiome 545
chr11:62,560,588–62,561,104 61.3 kb Distal (>10kb) Multiome 541
chr11:62,561,760–62,562,358 60.0 kb Distal (>10kb) Multiome 43
chr11:62,573,347–62,574,645 48.0 kb Distal (>10kb) Multiome 845
chr11:62,591,246–62,592,462 30.2 kb Distal (>10kb) Multiome 976
chr11:62,600,988–62,603,291 20.0 kb Distal (>10kb) Multiome 872
chr11:62,611,665–62,613,544 9.1 kb Proximal (<10kb) Multiome 737
chr11:62,621,550–62,622,445 71 bp At TSS Multiome 964
chr11:62,646,025–62,647,031 24.7 kb Distal (>10kb) Multiome 815
chr11:62,652,836–62,653,744 31.4 kb Distal (>10kb) Multiome 921
chr11:62,664,567–62,666,291 43.2 kb Distal (>10kb) Multiome 1020
chr11:62,671,328–62,672,522 49.8 kb Distal (>10kb) Multiome 882
chr11:62,705,543–62,707,930 84.3 kb Distal (>10kb) Multiome 760
chr11:62,708,691–62,710,293 87.6 kb Distal (>10kb) Multiome 531
chr11:62,726,557–62,728,947 105.6 kb Distal (>10kb) Multiome 1088
chr11:62,753,347–62,754,665 132.2 kb Distal (>10kb) Multiome 696
chr11:62,761,085–62,762,045 139.5 kb Distal (>10kb) Multiome 649
chr11:62,770,753–62,772,068 149.5 kb Distal (>10kb) Multiome 885
chr11:62,786,365–62,787,860 164.6 kb Distal (>10kb) Multiome 1073
chr11:62,791,569–62,792,385 170.0 kb Distal (>10kb) Multiome 805
chr11:62,804,451–62,807,080 183.5 kb Distal (>10kb) Multiome 994
chr11:62,831,037–62,832,904 210.0 kb Distal (>10kb) Multiome 870
chr11:62,839,042–62,842,743 219.4 kb Distal (>10kb) Multiome 1403
chr11:62,851,028–62,851,955 229.5 kb Distal (>10kb) Multiome 421
chr11:62,855,209–62,856,560 234.0 kb Distal (>10kb) Multiome 1071
chr11:62,862,252–62,862,948 240.7 kb Distal (>10kb) Multiome 360
chr11:62,880,343–62,881,977 258.9 kb Distal (>10kb) Multiome 1080
chr11:62,909,033–62,909,985 287.4 kb Distal (>10kb) Multiome 366

Genome Browser

Genomic view of the B3GAT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr11:62,327,140 – 62,919,985
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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