Transcription factors with Perturb-seq knockdown data for ATXN7L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATXN7L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATXN7L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:105,580,977–105,581,814 | 295.0 kb | Distal (>10kb) Multiome | 492 | |
| chr7:105,638,494–105,639,567 | 237.2 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr7:105,643,274–105,643,732 | 232.9 kb | Distal (>10kb) Multiome HiCAR | 211 | |
| chr7:105,651,976–105,652,948 | 223.9 kb | Distal (>10kb) Multiome HiCAR | 292 | |
| chr7:105,655,354–105,656,152 | 220.7 kb | Distal (>10kb) Multiome HiCAR | 203 | |
| chr7:105,657,015–105,657,727 | 219.2 kb | Distal (>10kb) Multiome HiCAR | 205 | |
| chr7:105,664,641–105,665,449 | 211.4 kb | Distal (>10kb) Multiome HiCAR | 422 | |
| chr7:105,689,008–105,690,124 | 187.1 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr7:105,695,816–105,698,274 | 179.2 kb | Distal (>10kb) Multiome | 292 | |
| chr7:105,849,145–105,849,924 | 26.8 kb | Distal (>10kb) Multiome | 308 | |
| chr7:105,876,091–105,877,586 | 223 bp | At TSS Multiome | 773 | |
| chr7:105,878,853–105,879,514 | 2.4 kb | Proximal (<10kb) | 37 | |
| chr7:105,962,909–105,963,831 | 86.9 kb | Distal (>10kb) Multiome | 169 | |
| chr7:105,990,565–105,991,288 | 114.4 kb | Distal (>10kb) Multiome | 112 | |
| chr7:106,009,291–106,010,280 | 133.2 kb | Distal (>10kb) Multiome HiCAR | 640 | |
| chr7:106,042,587–106,043,289 | 166.4 kb | Distal (>10kb) Multiome | 430 | |
| chr7:106,111,676–106,113,209 | 235.9 kb | Distal (>10kb) Multiome | 968 | |
| chr7:106,176,499–106,177,243 | 300.4 kb | Distal (>10kb) Multiome | 473 |
Genomic view of the ATXN7L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.